Microwave Assisted Synthesis, Characterisation and Biological Activities of Cu(II) Complexes of Few Thiosemicarbazones Ligands

Thiosemicarbazones are class of compounds which obtained by the condensation thiosemicarbazide with carbonyl compounds. The transition metal complexes thiosemicarbazones widely considered due to their broad spectrum biological activities such as antibacterial, antitumor and antifungal activities. In present research work a series four novel Cu(II) aryl having general composition [Cu(L1)2Cl2], [Cu(L2)2Cl2], [Cu(L3)2Cl2] [Cu(L4)2Cl2]{where L1= 4-nitroacetophenone (4NAT), L2 = 3-nitrobenzaldehyde thiosemicarbazone (3NBT), L3 4-hydroxybenzaldehyde (4HBT) L4 4-aminoacetophenone (4AAT)} have been synthesized reaction substituted aromatic aldehydes ketones conventional heating well microwave irradiations method followed complexation metal. characterised elemental analysis, melting point determination, FTIR, UV-visible spectral analysis. Thiosemicarbazone ligands behave bidentate ligand forms octahedral Cu(II). new screened in vitro for antibacterial activity against Escherichia coli, Staphylococcus aureus Bacillus subtilis bacteria. result shows that all potent agents these